They sought more than $455m (£272m) reimbursement for treating uninsured smokers who had not paid for care.
The hospitals treat many destitute, non-paying patients.
They said medical ethics required them to treat people in need, regardless of their ability to pay.
In the case, the hospitals claimed that tobacco companies manipulated the nicotine content in cigarettes and misrepresented the health effects of smoking.
But a jury in St Louis rejected their claim.
"The jury agreed with Philip Morris USA that ordinary cigarettes are not negligently designed or defective," said Murray Garnick of Philip Morris. (Say, what?)
An official from Lorillard, another company in the case, said: "Compelling evidence was presented to the jury, including testimony from hospital witnesses, that confirmed the hospitals were not financially damaged as they asserted." (Say, whaaat?)
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